Profhilo - Bio Remodelling
Profhilo - Bio Remodelling
Profhilo - Bio Remodelling
Profhilo - Bio Remodelling

PROFHILO H+L Bio Remodeling

PROFHILO H+L is the first stabilised hyaluronic acid (HA) based product manufactured without the use of chemical cross-linking agents (BDDE). It is used to reshape skin and treat sagging skin, not just fill lines and wrinkles. Content 1x2ml syringe


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PROFHILO® - Bio Remodeling

PROFHILO is the first stabilized Hyaluronic Acid (HA) based product manufactured without the use of chemical crosslinking agents (BDDE). It is used for skin remodeling and treating skin laxity, not just for filling in lines and wrinkles.

Profhilo is a new trend in WOW aesthetics . It is a stable hyaluronic acid injection that can be used to treat sagging skin.

Profhilo by IBSA is a highly pure hyaluronic acid. Thanks to a patented bio-fermentation process, it is classified as "top quality" worldwide. The product is characterized by purity, safety and high resistance to thermal production processes.

Content 1x2ml syringe

The pack contains 1 pre-filled syringe with 2 needles type 29G x ½” (0.33 x 12 mm)

- 2 ml pre-filled syringe (32 mg (H-HA) + 32 mg (L-HA) hyaluronic acid sodium salt in 2 ml buffered isotonic saline);

Medical device for intradermal use

Sterile - disposable product.


Profhilo is not designed as a dermal filler. As such, it's not as effective for adding volume, restricting movement, or sculpting. Instead, Prophilo's formulation improves tone, texture and elasticity. The result is a healthier, younger-looking complexion.

It dramatically improves tissue quality, even in difficult areas, and complements other aesthetic treatments and dermal filler procedures. Its effects can last from 6 to 9 months.

Profhilo can be used anywhere the skin needs rejuvenation, but most typically:

» cheek tops

» side of the face

» lines around the mouth

» nasolabial folds

» laugh lines

The particularly receptive BAP are injected with only 5 small injections per half of the face.

Profhilo - Bio Remodeling

It is an anti-wrinkle treatment that can turn back time and bring back natural beauty.

It is recommended that patients receive two treatments four to six weeks apart. Unlike many other dermal fillers and injectables, Prophilo is safe for multiple uses throughout the body.

The benefits of hyaluronic acid lend themselves very well to general treatment areas such as the face, neck and arms, as well as the underarms. abdomen and knees. The most widely used BAP chart is designed to provide the best guidelines for precise positioning for specific measurements for the face and neck. For example: see the description below. Compared to other injection methods, the innovative BAP-Profilo technology involves a significantly lower risk of bruising, redness and inflammation at the injection site.


The injection points are distributed over a large area in the subcutis and immediately bring about a fresh appearance. After PROFHILO® remains in the tissue longer, it stimulates intensive collagen formation.

Thanks to the special manufacturing process, PROFHILO® remains in the tissue 30 times longer than non-crosslinked hyaluronic acid (as found in mesotherapy products), where it develops its moisturizing and stimulating effect. PROFHILO® contains 64 mg of hyaluronic acid per 2 ml of product, making it one of the most concentrated hyaluron products on the world market.

PROFHILO® is injected with very fine needles at just 5 defined injection points on each side of the face. Due to its special fluidity, PROFHILO® spreads itself in the tissue. You can usually return to your usual everyday life immediately after the application.

A treatment cycle consists of at least 2 applications at intervals of 4 weeks. A refresher treatment is recommended after 4 to 6 months.

PROFHILO® - Bio Remodeling


Is Profhilo natural? Well, it's a non-surgical hyaluronic acid (it's found naturally in our bodies), so there's no need to add any chemicals. It is actually not a dermal filler or mesotherapy.

Traditionally, dermal fillers contain a synthetic chemical called BDDE. BDDE is short for 1,4-butanediol diglycidol, a magic ingredient that binds the entire hyaluronic acid chain to prevent the chain from breaking down in the body. It is inherently stable so there is no need to add chemicals. Therefore, it is not actually a dermal filler or a mesotherapy product, but a unique product in its own right.

PROFHILO® has a unique and patented formula. When exposed to heat, high and low molecular weight hyaluronic acid combine to form a hybrid molecule. This thermal crosslinking eliminates the need for additives (like BDDE), resulting in excellent product compatibility.

PROFHILO® is a high-purity hyaluronic acid that supplies the skin with moisture from the inside through a strong water-attracting effect, stimulates the body's own hyaluronic acid production and promotes the formation of elastin and collagen.


The absence of additives ensures the best possible tolerability and minimizes the risk of side effects.

PROFHILO® can be combined with all common fillers, PRP, laser and botulinum treatments.


Profhilo was awarded Product Innovation of the Year 2016 at the Aesthetics Awards 2016 in the UK and the International Anti-Aging and Beauty Trophy for Best Skin Improvement Product at the European Congress of Aesthetic and Anti-Aging Medicine in October 2015 in Paris. In 2018, PROFHILO® was awarded "Best injectable product".

The PROFHILO® treatment is fast, gentle and hardly noticeable.

Small amounts of PROFHILO® are injected with very fine needles at five defined injection points on each side of the face. Thanks to its special properties and the special BAP (Bio Aesthetic Points) injection technique, PROFHILO® is distributed in the tissue. The entire facial skin benefits from its moisturizing effect.

Immediately after the treatment you can return to your usual everyday life without any problems.

A treatment with two applications 4 weeks apart is usually sufficient to achieve a visible anti-aging effect. A refresher treatment is recommended after another 6 months. Of course, PROFHILO® can also be used on other parts of the body such as the décolleté, neck and back of the hand. Where the skin is tired and dry, PROFHILO® brings moisture and thus new freshness to the tissue.

Profhilo - Bios Remodeling

The BAP treatment techniques for face and neck

The BAP Technique (BAP = Bio Aesthetic Points)

This technique makes it possible to flood the entire face with PROFHILO® with only 5 small injections per half of the face using the finest cannula (29G TW).

The dosed amount of the particularly absorbent BAP points enables the broad diffusion of PROFHILO® into the subcutaneous tissue and creates a natural and long-lasting effect for a fresh appearance. PROFHILO® can be combined with all common cosmetic procedures (fillers and botox).

The BAP Technique (BAP = Bio Aesthetic Points)

This technique makes it possible to flood the entire face with PROFHILO® with only 5 small injections per half of the face using the finest cannula (29G TW).

The dosed amount of the particularly absorbent BAP points enables the broad diffusion of PROFHILO® into the subcutaneous tissue and creates a natural and long-lasting effect for a fresh appearance. PROFHILO® can be combined with all common cosmetic procedures (fillers and botox).

The IBSA recommends 2 sessions a month apart using the BAP technique (Bio Esthetic Points) to minimize risks and maximize the flowability of the product.

Five points for intradermal administration of PROFHILO® must be identified as follows:

1. Cheekbone protrusion . It is recommended to keep a distance of at least 2 cm to the lateral canthus (outer corner of the eye).

2. Base of the nose . A line connecting the nostril and tragus and a perpendicular line originating from the pupil must be drawn to locate the injection site at the intersection of the two lines.

3. Tragus . It is recommended to stay at least 1 cm anterior to the inferior border of the tragus.

4. Chin . A vertical line must be drawn at the center of the chin and a vertical line one-third the distance from the top of the vertical line. From the point of intersection, one should move 1.5 cm towards the corner of the mouth to find the injection point.

5. Mandibular angle . The fifth point is 1 cm above the mandibular angle.

Then 0.2 ml of the product must be injected into the deep dermal/subcutaneous levels using the bolus technique.

The injections should be followed by a gentle massage.


With its correcting/filling effect on natural and induced depressions in the skin, PROFHILO® starts:

» in the physiological process of skin aging, the effects of which include a decrease in skin hydration and changes in elastic fibers and skin collagen, which are accompanied by a loss of tautness and elasticity;

» in the process of dermal tissue repair that occurs in the case of scars caused by superficial injuries to the skin (eg acne and smallpox scars).

The viscoelastic and moisturizing properties of hyaluronic acid, combined with the maintenance of an adequate concentration of hyaluronic acid in the skin tissue, ensure rehydration of the skin and create optimal conditions to prevent and counteract skin aging, while promoting tissue remodeling and the consequent corrective effect on the sun exposure - and age-related

Damage caused by aging processes of the skin as well as any kind of scarring are promoted.


Hyaluronic acid also plays a role inside the extracellular matrix, creating the physiological conditions for the thriving, migration and organization of dermal cellular components. Furthermore, the intradermal administration of PROFHILO® and its action at the level of the dermis instead of the epidermis, allows the optimal amount of hyaluronic acid to be introduced directly into the tissues to be treated, in order to counteract the cytotoxic effect of free radicals on the fibroblasts and the underlying fatty layers, which ensures the effectiveness of preventive and corrective beauty medicine treatments.

The hyaluronic acid used in PROFHILO® is obtained from a natural substrate through biosynthesis without further chemical modification . Therefore, PROFHILO® has excellent biocompatibility and its application in the dermis allows integration with endogenous hyaluronic acid, which has been reduced and modified due to physiological aging processes of the skin or as a result of superficial skin injuries.

In addition, in vitro studies were conducted to determine any incompatibilities and/or interactions between PROFHILO® and platelet-rich plasma (PRP) . The results obtained show that the PRP does not alter the rheological behavior of sodium hyaluronate.

PROFHILO® is indicated for treatments to redefine facial and body contours and to model sagging areas. However, it is particularly indicated for the treatment of the area on and under the cheekbones, upper arm, abdomen and other areas affected by sagging skin.

An initial cycle of two treatments 30 days apart is recommended , which may be followed by maintenance treatments 2 months apart if necessary. In any case, it is advisable to evaluate the specific PROFHILO® protocol in adaptation to the individual degree of skin aging of the person being treated.


Currently, dermal fillers based on hyaluronic acid (HA) are the most popular procedure in dermo-aesthetic medicine to treat skin aging. Recent studies have shown that combining HA chains of different lengths and molecular weights enhances tissue repair and regeneration through a synergistic mechanism. Profhilo® is a product that has been on the market since 2015 and is based on stable, hybrid and cooperative complexes (HyCoCos) produced using NAHYCO® Hybrid Technology, an innovative thermal process that excludes the use of chemical reagents. The result is a filler with high biocompatibility and low viscosity that favors optimal diffusion at the tissue level to achieve the targeted bioremodeling of the facial contour. The aim of this review is to provide data from the entire post-marketing experience after 3 years of use and more than 40,000 patients treated with the medical device.

Launched in 2015, Profhilo® is IBSA 's novel HA preparation based on stable hybrid cooperative complexes (HyCoCos) and is the first product to be developed using NAHYCO® hybrid technology, an innovative thermal production process patented by IBSA .

The pack contains 1 pre-filled syringe with 2 needles 29 G × ½ (0.33 x 12 mm) with the following available volume: -2 ml pre-filled syringe - 32 mg (H - HA) + 32 mg (L - HA) hyaluronic acid sodium salt in 2 ml of buffered physiological sodium chloride solution. The pre-filled syringes are sterilized by moist heat and the needles are sterilized with ethylene oxide.

The manufacturing process starts with a simple mixture of 32 mg high molecular weight HA (1100-1400 kDa) and 32 mg low molecular weight HA (80-100 kDa). The mixture is then stabilized by the thermal process mentioned above, which does not use crosslinking agents and consists of a first high temperature step followed by a low temperature step.

The result is a product that promotes both the remodeling and tissue repair processes, even when scars have already formed. It also improves skin sagging on the face, neck and body.

PROFHILO® is indicated for the treatment of the face and body, especially for the treatment of the malar-zygomatic and submalar area. An initial cycle of two treatments 30 days apart is recommended, followed if necessary by maintenance treatments every 2 months. However, it is recommended to evaluate the specific PROFHILO® protocol according to the degree of aging of the patients.

Important NOTE:

As a seller, we point out that the injection of products with and without lidocaine should only be carried out by trained and medically qualified personnel, the medical and nursing sector.



Hyaluronic acid (HA) is a naturally occurring polysaccharide in the human body whose primary function is to maintain proper tissue hydration, thanks to its inherent ability to bind large amounts of water.

Hyaluronic acid sodium salt is composed of repeated disaccharide units of N-acetylglucosamine and sodium glucuronate chains and is a fundamental component of the extracellular matrix in most tissues, including the skin.

PROFHILO® is a buffered isotonic solution of high molecular weight (H-HA) and low molecular weight (L-HA) hyaluronic acid (HA) .

The hyaluronic acid used in this product, both high and low molecular weight, is obtained through a biofermentation process without chemical modification and is therefore extremely well tolerated. Furthermore, thanks to a special, patented treatment of the solution (NAHYCO® Hybrid Technology), the H-HA and L-HA chains contained in PROFHILO® interact with each other , creating unique rheological characteristics that allow administration of more highly concentrated HA without an increase in viscosity .

The formulation of hyaluronic acids with different molecular weights contained in PROFHILO® is based on the Hydrolift® Action. This innovative approach aims to counteract the physiological decline in the skin's hyaluronic acid levels, restoring hydration, elasticity and tone to the skin, combining in a synergistic way deep hydration with the mechanical action of a skin lift.

The other product components are: sodium chloride, sodium phosphate and water for injections.

Is Profhilo® a filler or a skin booster?

PROFHILO® is not a filler or skin booster. Fewer sessions are required and it provides more fluid intake.

PROFHILO is not a filler, but a hyaluronic acid gel with innovative bioremodeling properties. It forms four types of collagen and elastin, making it an effective treatment for sagging, dehydrated and tired skin in general.

PROFHILO solves the problem of dehydration and restores the skin's natural glow.

Is PROFHILO® better than dermal fillers?

It has already been established that while Profhilo offers similar benefits, it is not a skin booster.

Another popular treatment that many people confuse with Profhilo is exactly the same as Dermal Fillers. It is a bio-remodeling treatment that rejuvenates the skin's natural elastic and collagenous product.

Whilst fillers are ideal if you only want minor adjustments and enhancements to specific areas of your face such as cheeks or under the eyes etc., Profhilo is the cosmetic facial to choose if you want more comprehensive enhancements to your face.

How does Prophilo work?

Profhilo is made from the purest form of Hyaluronic Acid (HA), which is strategically injected into the top layers of the skin using a very small needle. It diffuses effortlessly into the skin, where it has a "restorative" effect on tissues, deeply hydrating them and starting their biological remodeling process. Unlike dermal fillers, which are used to increase volume, Profhilo is used to improve skin quality.

When will I see the first results from Profhilo?

The product remains on the skin for around 28 days, during which time it stimulates collagen and elastin production through the slow release of hyaluronic acid. Therefore, after 4 weeks the results will be more visible and after 8 weeks you will notice that your skin looks young, hydrated and radiant.

What are the benefits of Prophilo?

Profhilo triggers a tissue reaction known as " bioremodeling " that smooths, tightens and imparts an inner glow to the skin. In short, Profhilo reshapes sagging skin and fights imperfections.

It is not a replacement for fillers and botox and can be used in combination with these other treatments or as a standalone treatment.

Profhilo acts on skin quality and not on the muscle movements that cause wrinkles (muscle relaxation injections treat these) or on the volume loss of fat pads and filling of certain wrinkles (these problems are treated with dermal fillers).

PROFHILO helps to repair and rejuvenate the skin, tightening and defining your face, eliminating fine lines, expression lines and wrinkles and smoothing the skin while eliminating wrinkles and sagging skin.

Am I a suitable candidate for Profhilo?

Anyone showing signs of aging can receive Profhilo. The preferred age group for PROFHILO is between 40 and 50 years. But even people outside the above age group can use PROFHILO as a preventive treatment to keep their skin strong and in good condition.

What is the Profhilo treatment protocol?

It only takes two treatments a month apart to experience the benefits of PROFHILO on your skin, as you can see an effect in as little as a day or two depending on your skin type. For others, the effects may take a week or more to become apparent. However, the best results are usually seen 8 weeks after the first treatment.

On the face, only 5 injection points on each side of the face are required for optimal results.

It is injected just below the skin's surface, where it spreads quickly (because it lacks the cross-linking agent BDDE) and reacts with its own tissues to instantly boost moisture levels.

In Phase 2, over the next 4 weeks, the production of collagen and elastin in the dermis is increased, resulting in a youthful looking skin that is smooth, soft and firm.

The result of the treatment lasts up to six months.

Profhilo® can be used as a standalone treatment or in conjunction with other dermal fillers, laser treatments or Botox as part of a holistic approach to skin remodeling and revitalization.

Is Profhilo a safe treatment?

This treatment is very effective in restoring your youthful appearance.

As far as safety is concerned, PROFHILO is very biocompatible as it was developed from natural hyaluronic acid without the addition of chemical cross-linking agents .

PROFHILO complements all other cosmetic or aesthetic procedures by significantly improving the skin structure and supporting the underlying structures.

As with any injectable product, there is always a risk of minor bruising and swelling at the injection site, which usually resolves within 24 hours.

Is the treatment with Prophilo painful?

Thanks to the innovative injection technique used in a Profhilo treatment, only 5 small injections are required on each side of the face, making the treatment relatively quick and convenient.

Since Profhilo is injected directly under the skin at predetermined points using very fine needles, it is relatively painless; You may feel a brief stinging or scratching sensation, but it doesn't last long.

Patients may elect to have a local pain reliever or anesthetic prior to the Profhilo® treatment, but this is generally not necessary. The procedure is very quick and only takes about 10 minutes.

Immediately after the procedure, small bumps can be seen at the puncture site. These can usually be covered very easily and can take up to 24 hours to heal.

Are there contraindications for PROFHILO?

Contraindications include patients with bleeding disorders, immunocompromised people, pregnant women and people with unrealistic expectations. Book your personal consultation to find the best treatment for you.

How long do Prophilo® results last?

Results from Profhilo® can last anywhere from 6 to 12 months depending on your individual response and how the product is metabolized.

It is recommended to come for a one-time maintenance treatment every 3 months. This keeps the skin in an exceptional condition.

How should I behave after a PROFHILO treatment?

Don't touch your skin. This evening, avoid harsh skincare products like retinols and AHAs, we recommend avoiding vigorous exercise for 48 hours.

Anything that makes your face red (exercise, steam baths, sun) makes you more prone to bruising and swelling.

When should I not use the PROFHILO?

Pregnant or breastfeeding women and anyone who has an infection at the injection site. Also, anyone who has previously had an allergic reaction to a product, which is very, very rare. It is important that you discuss your medical history fully with your doctor so that he can assess whether or not the treatment is right for you.

Collagen and elastin are often mentioned at Profhilo. What is that?

Collagen and elastin are mentioned a lot in this post and in relation to skin health. You may be wondering why collagen and elastin are so important?

Collagen is the protein that makes up the majority of your skin at around 75-80%. Collagen plays a crucial role in strengthening skin and can actually contribute to elasticity and hydration.

Elastin is another important protein that, as the name suggests, is incredibly elastic and is found in connective tissue. It helps the skin return to its original shape and position when pinched and pricked. When elastin decreases, elasticity decreases and skin does not correct the problems that younger skin would correct.

What is the best way to prepare for a Profhilo treatment?

Below are some tips to optimize the outcome of your treatment:

- Avoid alcohol the day before the treatment. This way you can minimize the risk of bruising.

- Avoid taking aspirin, ibuprofen or other anti-inflammatory drugs in the week before treatment as this also increases the risk of bruising.

- If you are unwell with a cold virus, cold sores (herpes) or any other rash or condition, please call the clinic to see if you still need to come to your appointment. Your general health is very important for treatment.

- After the treatment, carefully follow the after-care instructions given to you by your doctor and do not apply anything else to the treated area unless this has been discussed beforehand.

Are there any side effects of Prophilo?

Common side effects of Profhilo are similar to other types of fillers and include easy bruising and swelling. The risks are the same as with other fillers and can include allergic reactions or infections, although these are extremely rare.

How much does Prophilo cost?

Between 250€ - 500€

Profhilo is injected according to a standard pattern of 2 millimeters distributed over 10 injection points, so the cost does not depend on the amount used.

The price you pay depends largely on your doctor's experience and location of the practice.

In summary: Is Prophilo worth it?

Yes, Profhilo is worth it, but you need to find out if it's the best treatment option for your specific facial and skin goals. Profhilo is suitable for all skin types and improves the aesthetics of every face. In case of dramatic changes in sagging skin or deep wrinkles, it is best to combine it with another treatment.

The special thing about profhilo is that expectations have to be realistic, that's the key. If anyone thinks their face will be miraculously lifted, they're wrong: That's where fillers, threads, or a treatment come in. If you only think about the quality of the skin, the radiance of the skin and the hydration of the skin. It's great because it's an injectable moisturizer!

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