Tool for healthcare professionals
PRP Knowledge Check
25 questions on blood components, the physics of centrifugation, tubes and anticoagulants, classification systems and regulatory basics. Every answer comes with a technical explanation, and the check ends with a result broken down by topic.
The knowledge check covers five topic areas with five questions each: density layering of blood and the distinction between platelet-rich plasma (PRP) and platelet-rich fibrin (PRF); the physics of centrifugation with RCF and RPM; tubes and anticoagulants; the published PRP classifications such as PAW and DEPA; and regulatory basics for medical devices. Questions and answer options are shuffled on every run.
The PRP Knowledge Check is intended for healthcare professionals and serves solely as a means of professional self-assessment. It does not replace training, instruction, instructions for use, manufacturer information, clinical guidance, or individual medical or legal assessment. The intended purpose and the instructions for use of the medical devices employed always take precedence.
Five topic areas
5 questions
Blood & fundamentals
Density layering, buffy coat, platelet biology, PRP versus PRF.
5 questions
Centrifugation & physics
RCF and RPM, rotor radius, radius gradient in the tube, braking behaviour.
5 questions
Tubes & anticoagulants
ACD-A, citrate, EDTA, fill volume, surface activation in PRF.
5 questions
Classification & evidence
PAW, DEPA, Dohan Ehrenfest, platelet dose and recovery rate.
5 questions
Regulation & practice
MDR classification, UDI, incident reporting, documentation, advertising law.
Topic areas
You can select more than one. Questions and answer options are shuffled on every run.
Please select at least one topic area.
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Result
Your result
PRP Knowledge Check · prpmed.de
Breakdown by topic area
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Scientific basis and sources
Selected technical and legal sources on which the questions in this knowledge check are based.
- Regulation (EU) 2017/745 on medical devices (MDR) — Annex VIII (classification rules 2 and 3), Article 27 and Annex VI Part C (UDI). (EUR-Lex)↗ opens in a new tab
- German Medical Devices Implementation Act (MPDG) — national implementation of the MDR, including vigilance. (Gesetze im Internet)↗ opens in a new tab
- German Medical Devices User Reporting and Information Ordinance (MPAMIV) — reporting of suspected serious incidents by operators and users. (Gesetze im Internet)↗ opens in a new tab
- Section 630f of the German Civil Code (BGB) — documentation of treatment and retention of the patient record. (Gesetze im Internet)↗ opens in a new tab
- German Act on Advertising in the Field of Healthcare (HWG) — advertising for medicinal products, medical devices and other remedies. (Gesetze im Internet)↗ opens in a new tab
- DeLong JM, Russell RP, Mazzocca AD. Platelet-rich plasma: the PAW classification system. Arthroscopy. 2012;28(7):998–1009. (PubMed)↗ opens in a new tab
- Magalon J, Chateau AL, Bertrand B, et al. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med. 2016;2(1):e000060. (PubMed)↗ opens in a new tab
- Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–167. (PubMed)↗ opens in a new tab
- Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author’s perspective. J Cutan Aesthet Surg. 2014;7(4):189–197. (PubMed)↗ opens in a new tab
- Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev. 2009;23(4):177–189. (PubMed)↗ opens in a new tab
- García-Bordes L, Escutia-Marí L, Vizcaíno-Navarro S, et al. Anticoagulant-dependent platelet morphological artefacts in platelet-rich plasma preparation: a prospective paired study comparing EDTA and sodium citrate with implications for orthobiologic therapy. Biomedicines. 2026;14(7):1578. (PubMed)↗ opens in a new tab
- Tsujino T, Takahashi A, Yamaguchi S, et al. Evidence for contamination of silica microparticles in advanced platelet-rich fibrin matrices prepared using silica-coated plastic tubes. Biomedicines. 2019;7(2):45. (PubMed)↗ opens in a new tab
- Renné T, Schmaier AH, Nickel KF, Blombäck M, Maas C. In vivo roles of factor XII. Blood. 2012;120(22):4296–4303. (PubMed)↗ opens in a new tab
Content reviewed: September 2026