The symphony of hearing: How the body's own PRP is giving new hope in otology

The symphony of hearing: How the body's own PRP is giving new hope in otology

Introduction: When the silence booms - The search for new ways to treat hearing loss

Imagine a world in which the subtle nuances of a melody, the comforting whisper of a loved one or the life-saving signal of an approaching vehicle slowly fade away.

For millions of people around the world, this is not a distant dystopia, but the creeping reality of hearing loss. Otology, the fascinating medical specialty dedicated to diseases of the ear and associated hearing and balance disorders, has always faced the daunting challenge of restoring, or at least preserving, this lost symphony of life.

While traditional approaches such as hearing aids and cochlear implants undeniably provide valuable services, research is increasingly focusing on regenerative therapies - approaches that not only alleviate symptoms but could potentially address the underlying damage to the delicate structures of the inner ear.

In this exciting field of regenerative medicine, one player in particular has made a name for itself in recent years: platelet-rich plasma, or PRP for short. Originally a star in orthopaedics and sports medicine, where it accelerates the healing of tendons and joints, PRP is now knocking on the door of otology with great promise. Could this concentrate of the body's own healing factors really be the key to breathing new life into damaged hair cells or improving the function of the auditory nerve?

This article takes you on a journey of discovery into the world of PRP in otology. We will shed light on the scientific basis, delve into current studies and discuss the potential of this innovative therapy, which has the potential to change the treatment of hearing disorders in the long term. Fasten your seatbelts - it will be a fascinating journey to the frontline of medical research!

The elixir in your own blood: what exactly is PRP and how does it unleash its healing powers?

Before we dive deeper into the specific applications of PRP in otology, let's pause for a moment and take a closer look at this fascinating endogenous product. What is behind the acronym PRP and why is it said to have such great regenerative potential? As is so often the case in medicine, the answer lies in the ingenious simplicity of nature itself.

The quintessence of healing: platelets and growth factors

In simple terms, platelet-rich plasma is a concentrate of blood platelets (thrombocytes) obtained from the patient's own blood. Imagine that your blood is a rich cocktail of different cells and substances. Using a special centrifugation process - a bit like a high-speed salad spinner for blood cells - the platelets are separated from the other components, such as the red and white blood cells, and concentrated into a small amount of plasma. The result is a golden yellow liquid that contains three to eight times more platelets than normal blood.

But why are these platelets so valuable? Platelets are far more than just the little helpers that rush to the scene of an injury to stop the bleeding. They are true powerhouses of regeneration, packed with a multitude of bioactive proteins, the so-called growth factors. These growth factors are the real conductors in the orchestra of healing. Names such as PDGF (Platelet-Derived Growth Factor), TGF-β (Transforming Growth Factor-beta), VEGF (Vascular Endothelial Growth Factor) or IGF-1 (Insulin-like Growth Factor-1) may sound technical at first, but their effect is impressive:

  • Cellular homing and activation: they attract other healing-promoting cells, such as stem cells and fibroblasts, to the site of action.
  • Tissue builders: They stimulate cell division (proliferation) and the development of new cells (differentiation).
  • Create supply lines: They promote the formation of new blood vessels (angiogenesis), which improves the supply of oxygen and nutrients to the damaged tissue.
  • Anti-inflammatory and protective shields: They can modulate inflammatory reactions and protect cells from programmed cell death (apoptosis).

The PRP effect in the inner ear: a hypothesis with potential

When applied to the delicate structures of the inner ear, where sensitive hair cells are responsible for converting sound waves into nerve impulses and the auditory nerve transmits these signals to the brain, an exciting picture emerges. The hypothesis is that the concentrated administration of these growth factors by PRP directly at the site of damage - for example by intratympanic injection into the middle ear, from where the substances can diffuse into the inner ear - could trigger a regenerative cascade. It is hoped that PRP:

  • Stimulate damaged but still living hair cells to regenerate or prevent their demise.
  • Improve the function of supporting cells in the inner ear, which are important for the survival of hair cells.
  • Optimizes blood circulation and oxygen supply to the inner ear.
  • Inflammatory processes, which often play a role in hearing disorders, are reduced.
  • Exerts neuroprotective effects on the auditory nerve and supports its regeneration.

It is this multi-layered mode of action that makes PRP such a promising candidate in regenerative otology. It is not about a single active ingredient, but about a whole symphony orchestra of the body's own healing messengers, which are used in a targeted manner to mobilize the body's self-healing powers.

A glimmer of hope for the inner ear: where PRP is already making waves in otology

Now that we have shed light on the fascinating mode of action of platelet-rich plasma (PRP), the exciting question arises: where exactly in the complex world of ear diseases could this endogenous elixir unleash its regenerative powers?

Research is in full swing here, and initial results point to promising areas of application, particularly in diseases that affect the sensitive inner ear. The focus here is primarily on intratympanic injections, a method in which PRP is injected directly into the tympanic cavity of the middle ear through the eardrum under microscopic control. From there, the valuable growth factors are supposed to reach the inner ear via the fine membranes of the round and oval window - a kind of express delivery to where it is needed.

Sensorineural hearing loss (SNHL): When the hair cells are silent

Sensorineural hearing loss is one of the most common forms of hearing loss and is caused by damage to the hair cells in the cochlea (the cochlea) or to the auditory nerve itself. There are many causes: Noise exposure, ageing processes (presbycusis), certain medications, genetic factors or even infections. For a long time, SNHL was considered largely irreversible. But PRP is raising new hope.

Inner ear
  • The vision: researchers hope that the growth factors in PRP can revitalize damaged but not yet dead hair cells, extend their lifespan and possibly even stimulate the regeneration of precursor cells. A protective effect on the auditory nerve and an improvement in microcirculation in the inner ear are also being discussed.
  • Initial studies - A cautious optimism: Several clinical studies have investigated the effect of intratympanic PRP injections in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) or chronic SNHL. Some of these studies report significant improvements in hearing thresholds and speech understanding in some of the treated patients, especially when treatment was given early after the onset of hearing loss. There are indications that PRP could achieve comparable or in some cases even better results than standard therapy with corticosteroids, especially in patients in whom corticosteroids are not effective enough or are contraindicated.
  • The challenge: The study situation is still heterogeneous. Patient groups, PRP production protocols and endpoints vary, which makes direct comparisons difficult. Larger, randomized and controlled studies are urgently needed to clearly demonstrate efficacy and define optimal treatment protocols.

Tinnitus: Soothe the phantom noise in your ear?

The agonizing ringing, buzzing or whistling in the ear, known as tinnitus, is an enormous burden for many sufferers. Tinnitus often occurs in conjunction with hearing loss and is interpreted as a kind of overactivity or dysregulation in the auditory system. Here, too, there are considerations as to how PRP could help.

  • The approach: It is thought that PRP could positively influence the underlying pathologies that contribute to tinnitus (e.g. damage to hair cells, neural dysfunction) through its regenerative and anti-inflammatory properties. Improved inner ear function could also indirectly reduce the perception of tinnitus.
  • State of research: Research into PRP for tinnitus is still in its infancy. Some small studies and case reports indicate a possible relief of tinnitus symptoms after intratympanic PRP administration, especially when the tinnitus is associated with sensorineural hearing loss. However, the results are often subjective and the study populations are small.
  • Outlook: Similar to SNHL, further well-designed studies are needed to more clearly define the role of PRP in tinnitus treatment. The complexity of tinnitus, which is often multifactorial, makes research here particularly challenging.
Tinnitus

Other potential fields of application: A look into the future

In addition to SNHL and tinnitus, there are other otologic diseases for which PRP could theoretically be beneficial:

  • Meniere's disease: a disease of the inner ear characterized by attacks of vertigo, hearing loss and tinnitus. The anti-inflammatory and regenerative properties of PRP could potentially have a positive effect here.
  • Perforations of the eardrum: Although surgical procedures are often used here, research is underway to determine whether PRP can support the healing of eardrum defects (often as a topical application or in combination with other materials).

It is important to emphasize that many of these applications are still experimental. However, intratympanic injection of PRP has shown promise as a way to deliver the regenerative potentials of this endogenous drug cocktail directly to the inner ear structures in need. The journey of PRP in otology has only just begun, but the first milestones are encouraging.

From theory to practice: the specific procedure of a PRP treatment in otology

The theoretical principles and potential applications of PRP in otology are fascinating, but how does such treatment actually work in practice? For physicians considering adding this innovative therapy to their treatment portfolio, a detailed understanding of the procedure is essential. In the following, we present the typical course of a PRP treatment for otologic indications, with a special focus on intratympanic application.

Step 1: Preparation and material selection

The quality of the PRP obtained depends crucially on the materials used. Specialized PRP tubes are essential for optimal platelet concentration and purity. The Vi PRP-PRO PRP tubes from https://prpmed.de/en/ have established themselves as a particularly efficient solution. These glass tubes with a wall thickness of 2.4 mm offer several decisive advantages:

  • High yield: up to 4-4.5 ml of highly concentrated PRP can be obtained from a 9 ml blood sample.
  • Precise separation: The special design enables optimum separation of the blood components.
  • Sterile processing: The tubes ensure contamination-free processing.
  • Flexibility: Depending on clinical requirements, various anticoagulants such as sodium citrate can be used.
  • In addition to the PRP tubes, the following materials are required for the treatment:
  • Centrifuge (with customizable settings for PRP collection)
  • Sterile syringes and cannulas (for blood collection and injection)
  • Local anesthetic (for anesthetizing the eardrum)
  • Microscope or endoscope (for precise visualization of the eardrum)
  • Sterilization equipment and protective clothing
PRP Extraction Process

Step 2: Blood sampling and PRP collection

The process begins with a simple venous blood collection from the patient:

  • Blood collection: approximately 9-10 ml of venous blood is drawn into a Vi PRP-PRO tube containing sodium citrate as an anticoagulant to prevent premature clotting.
  • Centrifugation: The tube is placed in a centrifuge. The optimal centrifugation parameters (speed and duration) vary depending on the protocol, but are typically around 1500-3000 rpm for 5-10 minutes. This process separates the blood into three layers:
  • Top: Platelet-poor plasma
  • Middle: Platelet-rich plasma (the "buffy coat" layer)
  • Bottom: Red blood cells
  • PRP extraction: The middle layer (PRP) is carefully extracted using a sterile syringe. The special design of the Vi PRP-PRO tubes facilitates this critical step and maximizes the yield of high-quality PRP.
  • Activation (optional): In some protocols, the PRP is activated prior to application by adding calcium chloride or thrombin to stimulate the release of growth factors. The necessity of this step is still under discussion in otology.
Blood collection and PRP extraction

Step 3: Intratympanic application

PRP is applied under sterile conditions and requires precision:

  1. Preparation of the patient: The patient is placed in a slightly reclined position with the ear to be treated facing upwards. The external auditory canal is cleaned and inspected under a microscope or endoscope.
  2. Local anesthesia: The eardrum is anesthetized with a local anesthetic, typically by applying a phenol solution or similar agent to a specific area of the eardrum.
  3. Myringotomy: A fine needle or myringotomy knife is used to make a small incision or puncture in the eardrum, typically in the posteroinferior-inferior quadrant.
  4. PRP injection: Approximately 0.5-1 ml of the harvested PRP is slowly injected through the myringotomy into the tympanic cavity. The use of a thin cannula (typically 25-27 gauge) minimizes trauma to the tympanic membrane.
  5. Positioning: After injection, the patient remains in the same position for approximately 30-60 minutes to allow optimal diffusion of the PRP through the round window into the inner ear and to prevent leakage.
Intratympanic application

Step 4: Aftercare and treatment regime

Aftercare and the treatment regime are crucial for success:

  • Immediate aftercare: the patient is instructed to avoid water in the ear for 24-48 hours and to avoid sudden changes in pressure (such as flying, diving or vigorous nose blowing).
  • Treatment frequency: The optimal treatment regimen is still the subject of research. Typical protocols include 1-3 injections 1-4 weeks apart, depending on the indication and individual response.
  • Audiologic follow-up: Regular hearing tests (pure tone audiometry, speech audiometry) and appropriate evaluations for tinnitus are essential to document treatment success.
  • Documentation: Careful documentation of the PRP protocol used, the injection technique and the clinical results is not only of great importance for patient care, but also for the further development of the method.

Aftercare and treatment regime

The use of high-quality materials such as the Vi PRP-PRO PRP tubes is a decisive factor for the quality and consistency of the PRP obtained. The special design of these tubes enables precise separation of the blood components and a maximum yield of highly concentrated PRP, which is particularly important in otology, where even small amounts of high-quality PRP can achieve significant effects.

It should be emphasized that PRP therapy in otology is still considered experimental and should ideally be performed in clinical trials or under careful documentation and follow-up. The continuous development of materials and protocols, as driven by products such as the Vi PRP-PRO tubes, is an important step towards the standardization and wider clinical application of this promising therapy.

Between hype and hope: The actual potential of PRP in otology - a critical appraisal

The insights so far into the world of platelet-rich plasma (PRP) and its potential applications in otology undoubtedly sound promising. The idea of using the body's own substances to regenerate damaged structures of the inner ear and alleviate hearing loss or tinnitus fires the imagination of doctors and patients alike.

However, as with any innovative therapy, it is crucial to keep a cool head and critically scrutinize the actual potential. Where do we really stand with PRP in otology? What does the current evidence say and what hurdles still need to be overcome?

The strengths of PRP: Why this approach is so attractive

The fascination with PRP is based on several convincing advantages:

  • Autologous and biocompatible: as PRP is obtained from the patient's own blood (autologous application), the risk of allergic reactions, rejection reactions or the transmission of diseases is extremely low. It is a natural approach that uses the body's own healing mechanisms.
  • Rich in growth factors: As described in detail above, PRP provides a broad spectrum of growth factors that can act synergistically to promote tissue regeneration and healing. This "cocktail" may be more effective than the administration of individual isolated factors.
  • Minimally invasive (with intratympanic injection): Intratympanic injection is a relatively uncomplicated and minimally invasive procedure that can be performed on an outpatient basis under local anesthesia. Compared to major surgical procedures on the ear, the stress for the patient is low.
  • Potential for treatment-resistant cases: PRP could be an option for patients in whom standard therapies (such as corticosteroids for sudden hearing loss) have not worked sufficiently or are contraindicated.
  • Low side effect rate (data to date): Studies to date on intratympanic PRP use generally report good tolerability with only mild and transient side effects such as mild pain at the injection site, dizziness or a transient sensation of pressure in the ear.
PRP treatment

The current evidence situation: a mosaic with many pieces

Although the theoretical rationale and preclinical data are promising, the clinical evidence for the efficacy of PRP in otology is still developing. It is important to take a differentiated approach here:

Promising signals, but no definitive evidence: Numerous small studies and case series, particularly on idiopathic sudden sensorineural hearing loss (ISSNHL), suggest positive effects. Some meta-analyses have attempted to summarize these results and conclude that PRP could be a safe and potentially effective treatment option, especially as salvage therapy.

prp studies
  • Heterogeneity of the studies: A major problem is the considerable heterogeneity of the studies to date. This concerns the inclusion criteria of the patients (type and severity of hearing loss, duration of the disease), the methods for PRP production (different centrifugation protocols lead to different platelet concentrations and leukocyte proportions), the number and frequency of injections and the endpoints used to evaluate success. These differences make it difficult to compare the results and draw general conclusions.
  • Need for high-quality studies: There is still a lack of large, randomized, placebo-controlled, double-blind studies - the gold standard of clinical research. Such studies are essential to prove the efficacy of PRP beyond doubt, identify optimal treatment parameters and define patient groups that could benefit most from the therapy.
  • Long-term results are often lacking: many studies only have short follow-up periods. Long-term data is required to assess the sustainability of the effects.

The untapped potential and future research directions

The potential of PRP in otology is considerable despite the current limitations in the evidence base. Future research should focus on the following aspects:

  • Standardization of protocols: Development and validation of standardized protocols for PRP production and application to ensure comparable results.
  • Biomarker identification: Research into biomarkers that could predict which patients will respond best to PRP therapy.
  • Combination therapies: Investigating the potential synergistic effects of PRP in combination with other therapies (e.g. corticosteroids, antioxidants, stem cell therapies).
  • Optimization of application routes: Although intratympanic injection is common, research into even more targeted and efficient ways of delivering the growth factors to the inner ear (e.g. using special carrier systems) could further improve efficacy.
  • Basic research: Further investigations into the exact mechanisms of action of PRP on the various cell types and structures in the inner ear.

The journey of PRP in otology is a marathon, not a sprint. It requires patience, careful scientific work and realistic expectations. But the findings so far give us reason to hope that we are at the beginning of a development that could expand the treatment options for hearing disorders in the future. It is an exciting field that is driving medical professionals and researchers worldwide to further unlock the secrets of the body's own regeneration - for a future in which the symphony of hearing can be preserved or restored for more people.

Conclusion: PRP in otology - an exciting chapter with an open end, written with the ink of hope

The journey through the world of platelet-rich plasma (PRP) and its role in otology is like immersing yourself in a rapidly developing field of research characterized by scientific curiosity, innovative thinking and a deep desire to open up new perspectives for patients with hearing disorders. We have seen how this concentrate of the body's own healing factors - extracted from the patient's own blood - has the potential to trigger regenerative processes in the sensitive inner ear. From the theoretical rationale, based on the synergistic effect of a variety of growth factors, to the first clinical studies, which are sending promising signals, especially in sensorineural hearing loss and tinnitus, the picture is full of possibilities.

Intratympanic injection has established itself as a common and minimally invasive way to deliver PRP to its potential target. The idea that damaged hair cells could be revitalized, the auditory nerve protected or inflammatory processes in the inner ear modulated is not only fascinating, but also a driving force for further research.

However, despite all the justified euphoria, it is crucial not to lose our scientific footing. As we have discussed, the current evidence base is still a mosaic with many pieces. The heterogeneity of the study protocols, the often small patient numbers and the lack of large, randomized, controlled studies require careful interpretation of the results to date. PRP is not a panacea and research is still in its infancy in many areas.

What remains is the realization that PRP in otology is more than just a passing trend. It represents a paradigm shift towards regenerative approaches that aim to address the causes of hearing disorders rather than just treating symptoms. The challenges are numerous - from the need for standardized protocols, to identifying patients who will benefit the most, to conducting high-quality, long-term studies.

For physicians, this means keeping up to date with the latest research, critically evaluating the possibilities and limitations of PRP and providing patients with transparent and comprehensive information. For patients, it means being hopeful, but also having realistic expectations and being aware that many applications are still at the experimental stage.

The story of PRP in otology continues to be written - with every new study, every scientific finding and every clinical experience. It is an exciting chapter in modern medicine, the end of which is still open, but which is filled with the ink of hope and the relentless pursuit of better treatment options for people with hearing loss. The symphony of hearing is too precious not to seize every opportunity to protect it and make it sound again.

Important note

Please note: This blog post is for informational and educational purposes for healthcare professionals only and does not constitute medical advice, diagnosis or treatment recommendations. The information presented here is based on the current state of scientific knowledge at the time of publication and is subject to change as a result of new research findings.

The use of platelet-rich plasma (PRP) in otology, particularly for specific indications, may still be considered experimental in some areas and may not be suitable for every patient or covered by all medical guidelines. The decision on a possible PRP treatment and its implementation must always be made individually by a qualified physician after careful consideration of the individual case and taking into account all relevant medical aspects and risks.

This article in no way replaces a personal consultation with a doctor or a professional medical examination. If you have any health complaints or questions about treatment options, please always consult your doctor or a specialist.

The authors and operators of this blog accept no liability for decisions made on the basis of the information provided here or for possible inaccuracies or omissions, although every care is taken to ensure that the content is accurate and up to date. Any reference to specific studies or treatment results is intended to illustrate scientific developments and does not imply any guarantee of similar results in individual cases. The mention of application methods such as intratympanic injection describes common procedures in studies and does not constitute a specific recommendation.

Bibliography: PRP in otology

  1. Singh, C. V., & Jain, S. (2024). The Role of Platelet-Rich Plasma in the Management of Sensorineural Hearing Loss: Current Evidence and Emerging Trends. . Cureus, 16(9), e68646.
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11451513/
    A comprehensive review highlighting the mechanisms, efficacy, safety and future directions of PRP in SNHL.

  2. Mustafa, M., Din, S. U., & Khan, A. M. (2024). Intratympanic Platelet-Rich Plasma Therapy for Sudden Sensorineural Hearing Loss: A Prospective Study. . Ear, Nose & Throat Journal, (epub ahead of print).
    https://pubmed.ncbi.nlm.nih.gov/39559101/
    A recent prospective study with 56 patients on intratympanic PRP therapy for sudden sensorineural hearing loss, which also reports improvements in tinnitus.

  3. El-Anwar, M. W., Nofal, A. A., Khazbak, A. O., & Sweed, A. M. (2024). Treatment of Sensorineural Hearing Loss in Children: Platelet Rich Plasma. . International Journal of Pediatric Otorhinolaryngology, 177, 111845.
    https://www.researchgate.net/publication/348982527_Treatment_of_Sensorineural_Hearing_Loss_in_Children_Platelet_Rich_Plasma
    This study investigated the efficacy and safety of intratympanic PRP injections in the treatment of SNHL in children.

  4. Abdel-Aziz, M., et al. (2024). Comparative study between Intratympanic Steroid Injection and Platelet-Rich Plasma in Sudden Sensorineural Hearing Loss. . Ain-Shams Journal of Medicine, 5(4).
    https://aimj.researchcommons.org/journal/vol5/iss4/41/
    This comparative study investigated the efficacy of intratympanic PRP injections versus dexamethasone in the treatment of sudden sensorineural hearing loss.

  5. Sharma, R., et al. (2025). A Prospective Study On Application Of Endoscopic Intratympanic Instillation Of PRP V/S Steroid Injection In Sudden Sensorineural Hearing Loss. . International Journal of Advanced Research, 13(1).
    https://www.journalijar.com/article/51936/a-prospective-study-on-application-of-endoscopic-intratympanic-instillation-of-prp-v/s-steroid-injection-in-sudden-sensorineural-hearing-loss/
    This prospective study compares endoscopic intratympanic instillation of PRP with steroid injections in SSNHL.

  6. Kania, R., et al. (2024). Management of Idiopathic Sudden Sensorineural Hearing Loss with Intratympanic Platelet-Rich Plasma. . Otolaryngology Poland, 78(3).
    https://otolaryngologypl.com/seo/article/01.3001.0054.4671/en
    This study reports on the safety and efficacy of PRP in the treatment of idiopathic sudden sensorineural hearing loss without systemic side effects.

Tinnitus and PRP

  1. Manohar, S. (2024). BPST Point in Tympanic Membrane: Point of Intra-tympanic PRP Instillation. . Otolaryngology Online Journal, 14(4).
    https://www.researchgate.net/publication/344642647_BPST_Point_in_Tympanic_Membrane_Point_of_Intra-tympanic_PRP_Instillation
    This article describes a specific technique for intratympanic PRP instillation focusing on a specific point in the tympanic membrane.

  2. Elzayat, S. (2025). Intratympanic Injections for Tinnitus Management: A Systematic Review. . Presented at the Tinnitus Research and Practice Congress, Warsaw.
    https://hearingreview.com/hearing-loss/tinnitus/tinnitus-research-and-practice-2025-warsaw-congress-highlights
    A systematic review of intratympanic injections, including PRP, for the treatment of tinnitus, presented at the Warsaw Congress 2025.

  3. Henton, A., & Tzounopoulos, T. (2024). What's the buzz? The neuroscience and the treatment of tinnitus. . Journal of Neuroscience Research.
    https://www.turnerscientific.com/wp-content/uploads/2024/06/henton-tzounopoulos-2021-what-s-the-buzz-the-neuroscience-and-the-treatment-of-tinnitus.pdf
    A comprehensive overview of the neuroscience and treatment of tinnitus, which also discusses regenerative therapies such as PRP.

  4. Langguth, B., et al. (2024). The Current State of Tinnitus Diagnosis and Treatment. . Frontiers in Neurology.
    https://www.zora.uzh.ch/id/eprint/261793/1/ZORA_261793.pdf
    An up-to-date overview of the current state of tinnitus diagnosis and treatment, including new approaches such as PRP.

Innovative applications and related studies

  1. Jiang, Y., et al. (2024). Intratympanic injection of MSC-derived small extracellular vesicles promotes spiral ganglion neuron survival and hearing recovery. . Biomedicine & Pharmacotherapy, 172, 116055.
    https://www.sciencedirect.com/science/article/pii/S0753332224012770
    This study investigates the effect of mesenchymal stem cell-derived extracellular vesicles, a regenerative approach related to PRP.

  2. Zhang, L., et al. (2025). Advances in the application of platelet-rich plasma in peripheral nerve injuries. . Neural Regeneration Research.
    https://link.springer.com/article/10.1007/s44254-025-00100-x
    An overview of the use of PRP in peripheral nerve injuries, which could also have implications for the auditory nerve.

  3. Mahmoud, S., et al. (2025). The role of platelet-rich plasma in biomedicine. . iScience, 27(3).
    https://www.sciencedirect.com/science/article/pii/S2589004224029328
    A comprehensive review of the role of PRP in biomedicine, including a comparative study of 50 patients with sensorineural deafness.

Meniere's disease and related studies

  1. Staab, J. P., et al. (2025). A modern conceptual framework for study and treatment of Menière's disease. . Frontiers in Neurology.
    https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1607435/full
    A modern conceptual framework for the study and treatment of Meniere's disease that also discusses regenerative therapy approaches.

  2. Gürkov, R., et al. (2025). Treating Meniere's disease with rimegepant. . Swiss Medical Weekly.
    https://smw.ch/index.php/smw/article/download/4147/6164/25576
    A study on the treatment of Meniere's disease that offers insights into new therapeutic approaches and can serve as a basis for comparison with PRP studies.

  3. Jiang, M., et al. (2024). Effect of betahistine on pro-inflammatory cytokine expression in patients with Ménière's disease. . Clinical Otolaryngology.
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11541603/
    A study on anti-inflammatory effects in Meniere's disease, relevant for understanding potential PRP effects.

  4. Patel, M., et al. (2024). The Autoimmune Hypothesis in Meniere's Disease. . Global Journal of Otolaryngology.
    https://juniperpublishers.com/gjo/pdf/GJO.MS.ID.556197.pdf
    An investigation of the autoimmune hypothesis in Meniere's disease relevant to understanding the potential immunomodulatory effects of PRP.

Note on research

This literature list represents a snapshot of current research on PRP in otology (as of May 2025). For continuous updating, I recommend regular searches in specialist medical databases such as PubMed, Embase or Cochrane Library. When evaluating studies, the study design, number of patients, methodology and possible conflicts of interest should always be taken into account.

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