Profhilo - Bio Remodelling
Profhilo - Bio Remodelling
Profhilo - Bio Remodelling
Profhilo - Bio Remodelling

PROFHILO H+L Bio Remodelling

PROFHILO H+L is the first stabilised hyaluronic acid (HA) based product manufactured without the use of chemical cross-linking agents (BDDE). It is used to reshape skin and treat sagging skin, not just fill lines and wrinkles. Content 1x2ml syringe


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PROFHILO® - Bio Remodeling

PROFHILO is the first stabilized hyaluronic acid (HA) based product manufactured without the use of chemical cross-linking agents (BDDE). It is used for skin reshaping and treatment of skin sagging, not only for filling lines and wrinkles.

Profhilo is a new trend in WOW aesthetics. It is a stable hyaluronic acid injection that can be used to treat sagging skin

Profhilo by IBSA is a highly purified hyaluronic acid. Through a patented bio-fermentation process, it is classified as "top quality" worldwide. The product is characterized by purity, safety and high resistance to thermal production processes.

Content 1x2ml syringe


Profhilo is not designed as a dermal filler. Therefore, it is not as effective to add volume, restrict movement or shape. Instead, Profhilo's formulation improves tone, texture and elasticity. The result is a healthier, younger-looking complexion.

It dramatically improves tissue quality, even in difficult areas, and complements other aesthetic treatments and dermal filler procedures. Its effects can last from 6 to 9 months.

Profhilo can be used anywhere the skin needs rejuvenation, but most typically:

- Tops of the cheeks

- Side of the face

- Lines around the mouth

- Nasolabial folds

- Laugh lines

With only 5 small injections per half of the face, the most receptive BAP are injected.

Profhilo - Bio Remodeling

It is an anti-wrinkle treatment that can turn back time and bring back natural beauty.

It is recommended that patients receive two treatments four to six weeks apart. Unlike many other dermal fillers and injections, Prophilo is safe for multiple applications throughout the body

The benefits of hyaluronic acid work well for general treatment areas such as the face, neck and arms, as well as the underarms. Abdomen and knees. The most common BAP card is designed to provide the best guidelines for precise positioning for specific measurements for the face and neck. For example: see the description below. Compared to other injection methods, there is much less risk of bruising, redness and inflammation at the injection site with the innovative BAP Profilo technology.


The injection points spread over a wide area in the subcutis and immediately produce a fresh appearance. After PROFHILO® remains in the tissue longer, it stimulates intensive collagen formation.

Due to the special manufacturing process, PROFHILO® remains in the tissue 30 times longer than uncross-linked hyaluronic acid (as found in mesotherapy products), where it unfolds its moisturizing and stimulating effect. PROFHILO® contains 64 mg of hyaluronic acid per 2 ml of product, making it one of the most concentrated hyaluronic products on the world market.

PROFHILO® is injected with very fine needles at only 5 defined injection points per half of the face. Due to its special flowability, PROFHILO® distributes itself in the tissue. Immediately after the application, you can usually return to your usual daily routine

A treatment cycle consists of at least 2 applications at intervals of 4 weeks. A booster treatment is recommended after 4 to 6 months

PROFHILO® - Bio Remodeling


Is Profhilo natural? Well, it is a non-surgical hyaluronic acid (it occurs naturally in our body), so it is not necessary to add any chemicals. It is not actually a dermal filler or mesotherapy

Traditionally, dermal fillers contain a synthetic chemical called BDDE. BDDE is short for 1,4-butanediol diglycidol, a magical ingredient that binds the entire hyaluronic acid chain to prevent it from breaking down in the body. It is naturally stable, so there is no need to add chemicals. Therefore, it is not actually a dermal filler or mesotherapy product, but a unique product unto itself

PROFHILO® has a unique and patented formula. When exposed to heat, high and low molecular weight hyaluronic acid combine to form a hybrid molecule. This thermal cross-linking eliminates the need for additives (such as BDDE), resulting in excellent product compatibility.

PROFHILO® is a high-purity hyaluronic acid that has a strong water-attracting effect that moisturizes the skin from within, stimulates the body's own hyaluronic acid production and promotes the formation of elastin and collagen.


The absence of additives ensures the best possible tolerability and minimizes the risk of side effects.

PROFHILO® can be combined with all common fillers, PRP, laser and botulinum treatments.


Profhilo was awarded Product Innovation of the Year 2016 at the 2016 Aesthetics Awards in the UK and the International Anti-Aging and Beauty Trophy for Best Skin Improvement Product at the European Congress of Aesthetic and Anti-Aging Medicine in Paris in October 2015. in 2018, PROFHILO® was crowned "Best injectable Product".

PROFHILO® treatment is fast, gentle and hardly noticeable.

At five defined injection points on each side of the face, tiny amounts of PROFHILO® are injected with very fine needles. Thanks to its special properties and the special BAP (Bio Aesthetic Points) injection technique, PROFHILO® is distributed throughout the tissue. The entire facial skin benefits from its moisturizing effect

Immediately after the treatment, you can return to your usual daily routine without any problems

One treatment with two applications at intervals of 4 weeks is usually sufficient to achieve a visible anti-aging effect. After another 6 months, a booster treatment is recommended. Of course, PROFHILO® can also be applied to other areas of the body such as the décolleté, neck and back of the hands. Where the skin is tired and dry, PROFHILO® brings moisture and thus new freshness to the tissue.

Profhilo - Bios Remodelling

The BAP treatment techniques for face and neck

The BAP technique (BAP = Bio Aesthetic Points)

This technique makes it possible to flood the entire face with PROFHILO® with only 5 small injections per half of the face using the finest cannula (29G TW).

The dosed amount of the particularly absorbent BAP points allows the wide diffusion of PROFHILO® into the subcutaneous tissue and creates a natural and long-lasting effect for a fresh appearance. PROFHILO® can be combined with all standard cosmetic procedures (fillers and Botox).

The BAP technique (BAP = Bio Aesthetic Points)

This technique makes it possible to flood the entire face with PROFHILO® with only 5 small injections per half of the face using the finest cannula (29G TW).

The dosed amount of the particularly absorbent BAP points allows the wide diffusion of PROFHILO® into the subcutaneous tissue and creates a natural and long-lasting effect for a fresh appearance. PROFHILO® can be combined with all standard cosmetic procedures (fillers and Botox).

IBSA recommends 2 sessions at one month intervals using the Bio Esthetic Points ( BAP) technique to minimize the risks and maximize the flowability of the product.

Five points for intradermal administration of PROFHILO® must be identified as follows:

1.Zygomatic prominence. It is recommended to maintain a distance of at least 2 cm from the lateral canthus (outer corner of the eye).

2.Base of nose. A line connecting the nostril and tragus and a perpendicular line extending from the pupil must be drawn to locate the injection site at the intersection of the two lines.

3.Tragus. It is recommended to stay at least 1 cm anterior to the lower edge of the tragus.

4.Chin. A vertical line at the center of the chin and a vertical line one-third of the distance from the top of the vertical line must be drawn. From the point of intersection, one should move 1.5 cm toward the corner of the mouth to find the injection point.

5.Lower jaw angle. The fifth point is located 1 cm above the angle of the mandible.

Then, 0.2 ml of the product must be injected into the deep dermal/subcutaneous levels using the bolus technique.

The injections should be followed by a gentle massage.


Currently, hyaluronic acid (HA)-based dermal fillers are the most popular dermo-aesthetic medicine intervention for the treatment of skin aging. Recent studies have shown that the combination of HA chains of different lengths and molecular weights improves tissue repair and regeneration through a synergistic mechanism. Profhilo® is a product that has been on the market since 2015 and is based on stable, hybrid and cooperative complexes (HyCoCos) produced using NAHYCO® Hybrid Technology, an innovative thermal process that eliminates the use of chemical reagents. The result is a filler with high biocompatibility and low viscosity that promotes optimal diffusion at the tissue level to achieve the desired bioremodeling of the facial contour. The objective of this review is to provide data from the entire postmarketing experience after 3 years of use and more than 40,000 patients treated with the medical device.

Launched in 2015, Profhilo® is a novel HA preparation from IBSA based on stable hybrid cooperative complexes (HyCoCos) and is the first product developed using NAHYCO® hybrid technology, an innovative thermal production process patented by IBSA.

The package contains 1 prefilled syringe with 2 needles 29 G × ½ (0.33 x 12 mm) with the following available volume: -2 ml prefilled syringe - 32 mg (H - HA) + 32 mg (L - HA) hyaluronic acid sodium salt in 2 ml buffered physiological sodium chloride solution. The prefilled syringes are sterilized by moist heat and the needles are sterilized with ethylene oxide.

The manufacturing process starts with a simple mixture of 32 mg of high molecular weight HA (1100-1400 kDa) and 32 mg of low molecular weight HA (80-100 kDa). The mixture is then stabilized by the above-mentioned thermal process, which does not use crosslinking agents and consists of an initial high-temperature step followed by a low-temperature step.

The result is a product that promotes both tissue remodeling and repair processes, even when scars have already formed. It also improves skin sagging on the face, neck and body.

PROFHILO® is suitable for the treatment of the face and body, especially for the treatment of the malar-zygomatic and submalar areas. An initial cycle of two treatments 30 days apart is recommended, followed, if necessary, by maintenance treatments every 2 months. However, it is recommended to evaluate the specific PROFHILO® protocol according to the patient's aging level.

The product exhibits unique properties such as high HA concentration (64 mg/2 ml), ideal manageability, optimal tissue diffusion and low viscosity, with fluidity predominating over elasticity (tan delta > 1).

In addition, HyCoCos have a high biocompatibility profile due to several features. First, HyCoCos are prepared by biosynthesis of a natural substrate without further chemical modification; second, their thermally stabilized natural HA has a duration similar to that of a weakly crosslinked gel.

Compared to other native HA formulations, HyCoCos exhibit the potential for more effective global bioremodeling, and the simultaneous presence of high and low molecular weight hyaluronan makes them a medical device that can be used in both aesthetic and regenerative medicine.

As the research shows, the hybrid complex formed from H-HA and L-HA promotes wound healing of human keratinocytes in vitro better than HA alone.

In addition, this particular combination increases the expression levels of type I and type III collagens and elastin.

Finally, HyCoCos have been shown to promote adipogenic differentiation and proliferation of adipose-derived stem cells (ASCs), which could be used to heal local tissue ischemia and scar formation and enhance adipose tissue renewal.

Over the past three years, these in vitro data have been validated and integrated with clinical studies that have confirmed both the efficacy and tolerability of the investigated medical product.

The in vitro and clinical studies have confirmed the innovative properties of the product. Therefore, after three years of marketing, the manufacturer has reviewed the post-marketing safety data to provide a complete and comprehensive description of the product profile.

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