Focus on skin quality
Developed for treatment concepts in which the condition and appearance of the skin are the primary considerations.
Rejuran Healer is an injectable skin booster based on highly pure polynucleotides (PN) to support skin quality as part of aesthetic treatment protocols.
– For the face, neck, and décolleté
– For use on structurally damaged, dry-looking, or mature skin
– Focuses on biostimulation rather than volume effect
– For injection by appropriately qualified medical professionals only
Medical device; use in accordance with the manufacturer's instructions for use (IFU). Package: 2 pre-filled syringes, 2 ml each.
PN skinbooster for medical professionals
Rejuran Healer is a PN-based injectable product for professional applications in which skin quality and tissue structure are the main focus. Unlike conventional fillers, the product is not primarily intended to add volume. It must only be administered by appropriately qualified medical professionals in accordance with the current manufacturer’s instructions for use.
Clear positioning within the treatment portfolio
Rejuran Healer is intended for practices that offer PN-based injection protocols as a distinct category alongside hyaluronic acid fillers, PRP or device-based procedures. The emphasis is not on immediate volume, but on a structure-focused approach within professional aesthetic treatment concepts.
Developed for treatment concepts in which the condition and appearance of the skin are the primary considerations.
Rejuran is not primarily used for contouring or for creating pronounced volume. This allows the product to be clearly differentiated during patient consultation.
The 2 × 2 ml pack supports transparent planning and documentation within professional practice workflows.
Material and origin
Polynucleotides, abbreviated as PN, are long-chain DNA fragments. According to the manufacturer, the PN used in Rejuran are obtained from salmon DNA and processed using the company’s proprietary DOT™ technology. The result is an injectable PN gel for professional medical-aesthetic applications.
This material class differs conceptually from cross-linked hyaluronic acid fillers: the focus is not mechanical volume enhancement, but its integration into protocols intended to support skin structure and skin quality.
Application areas
The selection of treatment area, technique, injection depth, product quantity and treatment interval is a medical decision. It must be based on the individual baseline situation, the indication and the current manufacturer’s information.
For professional applications in the facial area in accordance with the approved intended purpose and current IFU.
Suitability and technique must be assessed for each patient. Anatomical characteristics and risk zones must be taken into account.
Application must only take place following professional assessment and within a documented treatment plan.
Safety and professional responsibility
Check the packaging, batch number, expiry date, integrity and labelling of the supplied version.
Consider the patient’s medical history, skin condition, contraindications, allergies and previous treatments.
Injection technique, quantity, area and aftercare must be based on the manufacturer’s instructions and professional judgement.
Record the batch, product quantity, treatment area, date, informed consent and any relevant reactions in a traceable manner.
Product data
The European manufacturer and distribution information identifies REJURAN® as a Class III medical device bearing CE marking CE 2265. However, purchasing, supply and use must always be based on the labelling, conformity information and current IFU of the specific product version supplied.
Not for cosmetic use by unqualified users: The product must not be treated as a topical serum, microneedling product or freely usable ampoule.
Frequently asked questions from practices and purchasing teams
Rejuran Healer is an injectable PN product whose main focus is not conventional volume enhancement. It should therefore not be classified, either professionally or during patient consultation, in the same way as a conventional hyaluronic acid volumising filler.
PN stands for polynucleotides. These are long-chain DNA fragments used in Rejuran as processed material for medical-aesthetic injection protocols.
Only appropriately qualified medical professionals or professionals authorised under national law. The specific authorisation depends on the applicable national legislation and professional regulations.
The available product and manufacturer information identifies the face, neck and décolletage. The intended purpose stated in the current IFU of the supplied product version remains decisive.
A combination must not be assumed to be generally suitable. The practitioner must determine the sequence, interval, product compatibility and patient suitability on the basis of the respective IFU and the individual clinical situation.
No. Rejuran Healer is an injectable medical device and not a cosmetic microneedling serum. It is not intended for freely selected topical or cosmetic use.
Binding information is provided in the current manufacturer’s IFU for the supplied product version. It must be read in full before first use and remain available within the practice workflow.
For professional PN treatment concepts
Rejuran Healer combines a PN-based material concept with a practical pack format comprising two prefilled syringes of 2 ml each. Sale and use are restricted to qualified medical professionals; the current IFU and the labelling of the supplied batch always take precedence.
REJURAN® is a product line from the South Korean manufacturer PharmaResearch. The professional injectable products are based on polynucleotides (PN) from DNA-based source material. The international Rejuran portfolio includes several variants for different product-specific applications. This brand overview classifies the Rejuran products and distinguishes the injectable line from the separate REJURAN® Cosmetics range.
Rejuran is a PharmaResearch brand for PN-based products used in medical aesthetics. The classic injectable line is based on polynucleotides. PharmaResearch describes its proprietary DNA Optimizing Technology, or DOT™, in connection with these DNA-based materials.
Rejuran should not be equated generally with a cosmetic serum or a conventional hyaluronic acid volumising filler. The composition, intended purpose, storage and use of each specific product are determined by its labelling and current manufacturer information.
PharmaResearch markets several products internationally under the REJURAN® brand. The variants differ, among other things, in formulation and product-specific positioning.
The core variant of the injectable Rejuran line is based on polynucleotides (PN). It forms the basis of the internationally established REJURAN® product family.
REJURAN® i also belongs to the PN-based product family and is marketed by the manufacturer as a distinct variant within the international portfolio.
REJURAN® S is another specialised variant within the product family. The documentation for the respective market version is always decisive for its specific classification.
REJURAN® HB plus differs from the pure PN variants through a combined formulation that additionally contains sodium hyaluronate and lidocaine hydrochloride.
The international manufacturer portfolio does not automatically reflect availability or regulatory status in a particular country. The labelling, instructions for use and manufacturer documentation of the specific product version are always decisive.
The professional core line includes injectable PN-based products and product-specific combinations. They are intended for appropriately qualified users and must be assessed according to the current product labelling and manufacturer IFU.
PharmaResearch also markets topical skincare products under REJURAN® Cosmetics. According to the manufacturer, this cosmetics line uses ingredients including c-PDRN® and should not be confused with the injectable PN products.
PN and PDRN refer to DNA-based materials, but the terminology is not always used consistently in product communication and scientific literature. PharmaResearch identifies the material in the classic injectable REJURAN® line as PN – Polynucleotide; REJURAN® Cosmetics uses, among other ingredients, c-PDRN®.
A detailed professional overview of polynucleotides, Rejuran, hyaluronic acid and PRP is available in the prpmed article on polynucleotide skin boosters.
DOT™ stands for DNA Optimizing Technology. PharmaResearch uses this term for its proprietary technology for processing DNA-based source materials within its PN and PDRN product areas.
The manufacturer behind REJURAN® is PharmaResearch Co., Ltd. from the Republic of Korea. The company operates in several areas, including pharmaceuticals, medical devices and dermocosmetics, and uses DNA-based materials such as PN and PDRN across different product lines.
This brand page intentionally provides an overview only. Differences between polynucleotides, hyaluronic acid fillers and PRP, as well as the current evidence base, are discussed separately in the professional article.
prpmed offers Rejuran Healer 2 × 2 ml for appropriately qualified medical professionals. Product data, availability and ordering information are provided exclusively on the product page.
Rejuran is a PharmaResearch brand. The classic professional injectable line is based on polynucleotides (PN) and includes several product-specific variants.
The REJURAN® product line is manufactured by PharmaResearch Co., Ltd. in the Republic of Korea.
The international portfolio includes REJURAN®, REJURAN® i, REJURAN® S and REJURAN® HB plus, among others. Composition, intended purpose and availability vary by product version and market.
PharmaResearch identifies the material in the classic injectable REJURAN® line as PN – Polynucleotide. The manufacturer also uses PDRN or c-PDRN® in other product areas, so the terms should not be treated as universally interchangeable.
No. REJURAN® Cosmetics is a separate dermocosmetic skincare range with topical products and should not be confused with the professional injectable REJURAN® products.
prpmed offers Rejuran Healer 2 × 2 ml for appropriately qualified medical professionals. Price, pack contents and availability are listed on the product page.
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